Statistical challenges in genetic association analyses: Populationbased versus family-based studies
نویسندگان
چکیده
منابع مشابه
A powerful nonparametric statistical framework for family-based association analyses.
Family-based study design is commonly used in genetic research. It has many ideal features, including being robust to population stratification (PS). With the advance of high-throughput technologies and ever-decreasing genotyping cost, it has become common for family studies to examine a large number of variants for their associations with disease phenotypes. The yield from the analysis of thes...
متن کاملPedMerge: merging pedigrees to facilitate family-based genetic statistical analyses
SUMMARY PedMerge allows users to accurately and efficiently merge separately ascertained pedigrees that belong to the same extended family. In addition to validation checks of pedigree structure, the software provides files in LINKAGE or PEDSYS format that easily allow to be used by a variety of genetic statistical software packages including LINKAGE, SOLAR, SLINK or can be further manipulated ...
متن کاملStatistical significance in genetic association studies.
Clinical & Investigative Medicine (CIM) is receiving an increasing number of reports of candidate-based association studies. The track record of such studies in the past has been poor: numerous genetic associations reported from candidate gene studies have not been replicated in later studies.1 The rise of the genomewide association study (GWAS) is changing this situation. A well-designed GWAS ...
متن کاملCovariate adjustment in family-based association studies.
Family-based tests of association between a candidate locus and a disease evaluate how often a variant allele at the locus is transmitted from parents to offspring. These tests assume that in the absence of association, an affected offspring is equally likely to have inherited either one of the two homologous alleles carried by a parent. However, transmission distortion was documented in famili...
متن کاملTitle: A powerful non-parametric statistical framework for family-based association analyses
The Framingham Heart Study dataset used for the analyses was obtained from the National Center for Biotechnology Information database of genotypes and phenotypes (NCBI dbGaP) through accession number phs000128.v3.p3. ABSTRACT Family-based study design is commonly used in genetic research. It has many ideal features, including being robust to population stratification (PS). With the advance of h...
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ژورنال
عنوان ژورنال: Indian Journal of Genetics and Plant Breeding (The)
سال: 2019
ISSN: 0019-5200,0019-5200
DOI: 10.31742/ijgpb.79s.1.19